A unique capability of QCI Interpret is the ability to recognize and interpret genetic factors that span multiple variants, matching combination variants that can influence the selection of an appropriate treatment or clinical trial. QCI Interpret integrates ACMG guidelines and the AMP/ASCO/CAP tiering system into the QIAGEN Knowledge Base, a vast and expertly-curated repository of medical and scientific literature, including up-to-date information on approved drugs and clinical trials. By detailing supporting evidence for potential treatments and clinical trials, QCI Interpret offers full transparency to clinical actionability and pathogenicity assessments. Each piece of supporting clinical evidence is rated and linked to the source publication for further study if needed, and laboratories may also change variant assessments based on their experience, tracking all changes in compliance with standard clinical procedures.
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